| Model | ASUS PRIME B650M-K |
| Form Factor | micro-ATX (9.6" × 8.7" / 24.4 × 22.1 cm) |
| CPU Socket | AMD AM5 |
| CPU Support | AMD Ryzen™ 9000 / 8000 / 7000 Series Desktop Processors |
| Chipset | AMD B650 |
| Memory Slots | 2 × DDR5 DIMM |
| Max Memory | Up to 96GB |
| Memory Speed | DDR5 8000+(OC) to 4800 |
| Memory Features | Dual Channel, ECC & Non-ECC (Un-buffered), AMD EXPO™, OptiMem II |
| Integrated Graphics Output | 1 × HDMI 2.1 (4K@60Hz), 1 × VGA |
| Expansion Slots | 1 × PCIe 4.0 x16, 2 × PCIe 4.0 x1 |
| Storage Support | 2 × M.2, 4 × SATA 6Gb/s |
| M.2 Slots | PCIe 5.0 x4 (Ryzen 7000/9000), PCIe 4.0 x4 |
| RAID Support | RAID 0/1/10 (PCIe & SATA) |
| Ethernet | Realtek 2.5Gb Ethernet |
| Rear USB Ports | 2 × USB 3.2 Gen 2, 2 × USB 3.2 Gen 1, 4 × USB 2.0 |
| Front USB Support | USB-C® Gen 1, USB 3.2 Gen 1, USB 2.0 |
| Audio | Realtek 7.1 HD Audio (24-bit/192kHz) |
| Audio Features | Audio Shielding, Premium Capacitors, Dedicated PCB Layers |
| Back Panel I/O | HDMI, VGA, USB ports, 2.5Gb LAN, Audio jacks, BIOS FlashBack™, PS/2 |
| Fan Headers | 1 × CPU Fan, 2 × Chassis Fan |
| RGB Headers | 2 × Addressable Gen 2, 1 × Aura RGB |
| Power Connectors | 24-pin ATX, 8-pin CPU |
| Special Features | ASUS 5X PROTECTION III, Q-Design, EZ DIY |
| Thermal Design | M.2 Heatsink, VRM Heatsink |
| RGB Sync | ASUS Aura Sync |
| Software | Armoury Crate, AI Suite 3, Fan Xpert 2+, ASUS CPU-Z |
| BIOS | 256Mb UEFI AMI BIOS |
| BIOS Utilities | EZ Flash 3, CrashFree BIOS 3, EZ Mode |
| Manageability | Wake-on-LAN, PXE |
| Operating System | Windows® 11 / Windows® 10 64-bit |
| Accessories | SATA Cables, I/O Shield, M.2 Hardware, User Guide |